Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
Robenidine HCL
CAS: 25875-50-7
Molecular Formula: C15H14Cl3N5
Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride - Names and Identifiers
| Name | Robenidine HCL |
| Synonyms | Robenidine HCL Robenidine hyd Robenidine HCL Pure Robenidine Hydrochoride Robenidine hydrochloride KhiMcoccid Hydrochloride ChiMcoccid Hydrochloride 1,3-Bis(4-chlorobenzylideneaMino)guanidine Hydrochloride Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride 2,2'-Bis[(4-chlorophenyl)Methylene]carboniMidic Dihydrazide Hydrochloride (1E)-2-{(E)-amino[(2E)-(4-chlorobenzylidene)hydrazinylidene]methyl}-1-(4-chlorobenzylidene)hydrazinium chloride |
| CAS | 25875-50-7 |
| EINECS | 247-307-8 |
| InChI | InChI=1/C15H13Cl2N5.ClH/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12;/h1-10H,(H3,18,21,22);1H/b19-9+,20-10+ |
Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride - Physico-chemical Properties
| Molecular Formula | C15H14Cl3N5 |
| Molar Mass | 370.66 |
| Melting Point | 252-254°C |
| Boling Point | 488.1°C at 760 mmHg |
| Flash Point | 249°C |
| Solubility | Robenidine hydrochloride possesses a weak solubility in water (<1 mg/L), but is soluble in organic solvents: 94 mg/L in dimethylsulfoxide, 46 mg/L in dimethylformamide, 20 mg/L in pyridine and 6.3 mg/L in ethanol (95%). The Log Kow is 3.3 (EFSA, 2004a). |
| Vapor Presure | 1.12E-09mmHg at 25°C |
| Appearance | White crystal |
| Storage Condition | 0-6°C |
| Physical and Chemical Properties | White or yellowish crystalline powder, odorless, taste slightly bitter. Melting point 176 °c. Very slightly soluble in ether and water, soluble in dilute acid or dilute alkali, light color gradually darkened. |
| Use | Anti-coccidiosis drugs, acute or chronic chicken coccidiosis have a good effect |
Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 2 |
| RTECS | ME8651000 |
Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride - Nature
Open Data Verified Data
chlorobenzoguanidine hydrochloride white crystalline powder, odorless, bitter taste. The melting point was 243-244 °c. Soluble in ethanol, slightly soluble in water, almost insoluble in chloroform and ether. The color gradually darkened after light exposure.
Last Update：2024-01-02 23:10:35
Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride - Preparation Method
Open Data Verified Data
from sodium chlorate and hydrazine hydrate addition, rearrangement, and finally by the condensation of formaldehyde in ethanol prepared.
Last Update：2022-01-01 10:11:14
Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride - Use
Open Data Verified Data
It has the characteristics of broad spectrum, high efficiency, low toxicity, wide safety range, good palatability and promoting the development of body length. Can be used for the prevention and treatment of chicken, rabbit coccidiosis excellent drugs, zoonotic toxoplasmosis have prevention and treatment.
Last Update：2022-01-01 10:11:14
Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride - Reference Information
| use | as an antibacterial agent, it is effective against staphylococcus, hemolytic streptococcus, etc. Mainly used to treat avian cholera, avian typhoid fever, chicken autumn worm disease, etc. chlorobenzidine is a low-toxic and efficient anticoccidial drug, which can be used in chicken feed with a small dosage of 30-36g/t. it is forbidden during laying and the drug withdrawal period is 7 days. It can also be used in rabbit feed with a dosage of 50-66g/t. It is forbidden during pregnancy and the drug withdrawal period is 7 days. The new high-efficiency anti-coccidiosis drug has high curative effect, low toxicity and good palatability. It has good effects on acute or chronic chicken coccidiosis. Check the weight gain rate and feeding compensation of rabbits and poultry in the headquarters. This product is a variety of income from the the People's Republic of China Veterinary Pharmacopoeia (1990 edition, part 1). Anti-coccidiosis drugs have good effects on acute or chronic chicken coccidiosis. |
| production method | p-chlorobenzaldehyde is condensed with N,N'-diaminoguanidine hydrochloride. Preparation of N,N'-diaminoguanidine hydrochloride (1,3-Diaminoguanidine monohydrochloride,CH7N5 · HCl,[36062-19-8]): starting from sodium thiocyanate, thiosemicarbazide is prepared by addition and rearrangement with hydrazine hydrate. Then methylate dimethyl sulfate and hydrazinolysis were used to prepare N,N'-diaminoguanidine hydrochloride. Finally, calcium ammoniate was replaced with N,N'-diaminoguanide hydrochloride. Thiosemicarbazide is formed by the addition and rearrangement of sodium thiocyanate with water and hydrazine. Then methylate dimethyl sulfate and hydrazine to obtain N.N '-diaminoguanidine sulfate. Then replace calcium chloride with N.N '-diaminoguanidine hydrochloride. Finally, chlorobenzuanidine hydrochloride was prepared by condensation with p-chlorobenzaldehyde in reethanol with 94% yield. Sulfaamidine is used as raw material and is obtained by cyclizing with acetylacetone. Put sulfaamidine, acetylacetone, sodium bisulfite, sodium hydroxide and water into the reaction kettle, and heat and reflux for about 6 hours. When crystallization appears in the reaction solution, the reflux continues for 20h after adding acetylacetone. After recovering acetylacetone, add an appropriate amount of boiling water, filter while hot, and the filter cake is washed with hot water, recrystallized, and dried to obtain sulfamethazine. |
Last Update：2024-04-10 22:29:15
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View History
Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
6-Hydroxy-3-pyridinecarboxaldehyde
苯基 1-硫代-4-O-乙酰基-2,6-二-O-苯甲酰基-β-D-吡喃半乳糖苷
b-Cyclodextrin,2-hydroxyethylethers
ETHYL 7-METHYL-2-PHENYLPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE
1-苄基-4-苯基哌啶-4-甲腈
(S)-DIETHYL 2-(TERT-BUTOXYCARBONYLAMINO)PENTANEDIOATE(WX665212)
丝氨酸乙酯盐酸盐
EDTA-FeNH4H2O
乙酰羟肟酸乙酯
6-Hydroxy-3-pyridinecarboxaldehyde
苯基 1-硫代-4-O-乙酰基-2,6-二-O-苯甲酰基-β-D-吡喃半乳糖苷
b-Cyclodextrin,2-hydroxyethylethers
ETHYL 7-METHYL-2-PHENYLPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE
1-苄基-4-苯基哌啶-4-甲腈
(S)-DIETHYL 2-(TERT-BUTOXYCARBONYLAMINO)PENTANEDIOATE(WX665212)
丝氨酸乙酯盐酸盐
EDTA-FeNH4H2O
乙酰羟肟酸乙酯